Background: Airway eosinophilia is frequently observed during acute exacerbation of
asthma. Interleukin-5 (IL-5) and eotaxin are directly involved in the airway eosinophilia
found in persistent asthma. Interrelation between these cytokines is expected to occur in
acute exacerbation of asthma. Thus, we evaluated the relevance of interaction between
eotaxin and IL-5 in the airway inflammation of acute exacerbation. Methods: We measured
the number of inflammatory cells and the amount of eotaxin and IL-5 in sputum from 22 …

Background: Airway eosinophilia is frequently observed during acute exacerbation of
asthma. Interleukin-5 (IL-5) and eotaxin are directly involved in the airway eosinophilia
found in persistent asthma. Interrelation between these cytokines is expected to occur in
acute exacerbation of asthma. Thus, we evaluated the relevance of interaction between
eotaxin and IL-5 in the airway inflammation of acute exacerbation. Methods: We measured
the number of inflammatory cells and the amount of eotaxin and IL-5 in sputum from 22 …